动脉粥样硬化的中医证型、证素及用药规律分析OA

Objective:To explore the medication rules of traditional Chinese medicine(TCM)prescriptions for treating atherosclerosis(AS)in Jiangxi Hospital of Traditional Chinese Medicine by using data mining technology,so as to provide references for optimizing clinical treatment approach.Methods:In the past ten years,the clinical data of AS patients treated in the outpatient,emergency and inpatient departments of Jiangxi Hospital of Traditional Chinese Medicine were collected.By using bibliometric methods,frequency analysis,and association rule analysis,the TCM syndrome types,syndrome element classifications,and medication rules of AS prescriptions were summarized.Results:In the study of TCM for AS,88 patients who met the inclusion and exclusion criteria were finally included.A total of 238 TCM prescriptions were involved.The most frequently used TCM were Fuling(Poria),Chenpi(Pericarpium Citri Reticulatae),Fabanxia(Rhizoma Pinelliae Praeparatum),etc.The distribution of drug natures and flavors was mainly cold and warm,bitter and sweet,and mostly belonged to the liver and lung meridians.The categories of TCM mainly included tonifying deficiency drugs,promoting blood circulation and removing blood stasis drugs,and heat-clearing drugs.Association rule analysis showed that Wuweizi(Fructus Schisandrae Chinensis)-Maidong(Radix Ophiopogonis),Dilong(Pheretima)-Chuanxiong(Rhizoma Ligustici Chuanxiong)were the couplet medicinals with the highest support degree,and Rougui(Cortex Cinnamomi)-Sigualuo(Retinervus Luffae Fructus)were the couplet medicinals with the highest lift.High-frequency prescriptions were Shengmai Yin combined with the Gualou Xiebai Banxia decoction(生脉饮合瓜蒌薤白半夏汤),the Xuefu Zhuyu decoction(血府逐瘀汤),Tianma Yin(天麻饮),etc.A total of 77 articles were ultimately included in the study on TCM syndrome types and elements,comprising 64 articles on syndrome types,with the highest proportions being phlegm-damp obstruction syndrome,phlegm-stasis interaction syndrome,and Qi(气)deficiency with blood stasis syndrome.Additionally,13 articles focused on TCM elements,with the top three being blood stasis,Qi deficiency,and phlegm-dampness turbidity.Conclusion:The TCM treatment ideas for AS are mainly promoting blood circulation and removing blood stasis,tonifying and regulating Qi,clearing heat and relieving exterior symptoms.High-frequency TCM and prescriptions mostly involve the effects of promoting blood circulation and dredging collaterals and nourishing and tonifying,which are closely related to the mechanism of AS with blood stasis blocking collaterals and deficiency in origin and excess in branch,and in line with the TCM treatment principles of AS.