不同灸法对肺癌患者免疫功能干预效果的网状Meta分析OA

Objective:By conducting a network meta-analysis,to rank the efficacy of various moxibustion therapies on immune function in lung cancer patients and identify the optimal intervention from the perspective of evidence-based medicine.Methods:Randomized controlled trials(RCTs)evaluating the impact of moxibustion on immune function in lung cancer were retrieved from CNKI,Wanfang,VIP,CBM,PubMed,Web of Science,Embase,CINAHL,and Cochrane Library,from their inception to March 20,2025.Risk of bias was assessed using RoB 2.0 criteria.A Bayesian network Meta-analysis was performed using RevMan 5.4 and Stata 18.Results:Seventeen studies involving 1 472 patients and 7 types of moxibustion were included,with treatment durations ranging from 14 to 105 days.For CD3+,the probability ranking of interventions was:heat-sensitive moxibustion,wheat-grain moxibustion,the Yiqi Yangyin decoction(益气养阴汤),thunder-fire moxibustion,mugwort moxibustion,warm-needle moxibustion,governor vessel moxibustion,the Yiqi Jianpi Fang(益气健脾方),and routine treatment.For CD4+,the ranking was:the Yiqi Yangyin decoction,heat-sensitive moxibustion,governor vessel moxibustion,warm-needle moxibustion,thunder-fire moxibustion,mugwort moxibustion,wheat-grain moxibustion,the Yiqi Jianpi Fang,and routine treatment.For CD8+,the ranking was:heat-sensitive moxibustion,governor vessel moxibustion,the Yiqi Jianpi Fang,warm-needle moxibustion,wheat-grain moxibustion,thunder-fire moxibustion,mugwort moxibustion,and routine treatment.For CD4+/CD8+,the ranking was:governor vessel moxibustion,indirect moxibustion,heat-sensitive moxibustion,warm-needle moxibustion,thunder-fire moxibustion,mugwort moxibustion,wheat-grain moxibustion,the Yiqi Yangyin decoction,the Yiqi Jianpi Fang,and routine treatment.Conclusion:Across immune markers and clinical applicability,heat-sensitive moxibustion exerted the most favorable effect in enhancing immune function in lung cancer patients,followed by Qi(气)-tonifying herbal decoctions.Clinically,heat-sensitive moxibustion supplemented with Qi-tonifying formulas may be given priority.However,given the limited sample sizes and lack of syndrome differentiation in the included trials,further high-quality RCTs are warranted to confirm the findings.