化痰泻火方辅助治疗女童肥胖合并中枢性性早熟痰热内蕴证34例临床观察OA

Objective To observe the clinical efficacy of the Huatan Xiehuo Fang(化痰泻火方)as adju-vant therapy in obese girls with central precocious puberty(CPP).Methods A total of 68 obese girls with CPP of phlegm-heat accumulation pattern,who visited the department of pediatrics of The Second Affiliated Hospi-tal of Shaanxi University of Chinese Medicine from March 2024 to September 2025,were selected.Using a non-randomized concurrent control study design,they were divided into a control group and a treatment group,with 34 cases in each group.The control group received subcutaneous injections of GnRHa(Leuprorelin for Injec-tion).The treatment group received oral administration of the Huatan Xiehuo Fang in addition to the same treat-ment as the control group.Both groups were treated continuously for 3 months,after which clinical efficacy was assessed.Results The total effective rate was 88.24％(30/34)in the control group and 94.12％(32/34)in the treatment group,with no statistically significant difference between the two groups(P＞0.05).Before treat-ment,there was no statistically significant difference in glucose and lipid metabolism indices between the two groups(P＞0.05),indicating comparability.After treatment,total cholesterol(TC)and triglyceride(TG)lev-els in the control group significantly increased compared to before treatment within the same group(P＜0.05),while blood glucose,high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)levels showed no significant changes(P＞0.05).In the treatment group,blood glucose,TC,TG,and LDL-C levels significantly decreased,and HDL-C levels significantly increased after treatment compared to be-fore treatment within the same group and compared to the control group after treatment(all P＜0.05).Before treatment,there was no statistically significant difference in imaging indices between the two groups(P＞0.05),indicating comparability.After treatment,Tanner stage,ovarian volume,follicle count,and maximum follicle diameter significantly decreased in both groups compared to before treatment within the same group(all P＜0.05),while uterine length did not change significantly in either group(P＞0.05).The decreases in Tanner stage,ovarian volume,and follicle count were more significant in the treatment group(P＜0.05).Before treat-ment,there was no statistically significant difference in sex hormone levels between the two groups(P＞0.05),indicating comparability.After treatment,luteinizing hormone(LH),estradiol(E2),and follicle-stimulating hormone(FSH)levels in the treatment group significantly decreased compared to before treatment within the same group(all P＜0.05),and the decreases were more significant compared to the control group(P＜0.05).FSH levels in the control group did not change significantly(P＞0.05).Vitamin D levels and height growth ve-locity in the treatment group were significantly higher than those in the control group,while body weight growth velocity was significantly lower(all P＜0.05).There was no statistically significant difference in insulin-like growth factor-1(IGF-1)levels between the two groups(P＞0.05).Conclusion Huatan Xiehuo Fang as adju-vant therapy in obese girls with CPP of phlegm-heat accumulation pattern can significantly improve glucose and lipid metabolism,imaging indices,sex hormone levels,and growth and development status.It is worthy of clinical promotion and application.