基于JAK2/STAT3信号通路探究针刺治疗卒中后认知障碍的作用机制OA

This study focuses on the mechanism of acupuncture treatment for post-stroke cognitive impairment(PSCI),with a particular emphasis on its regulatory effect on the JAK2/STAT3 signaling pathway.The occurrence and development of PSCI are closely related to neuroinflammation,oxidative stress and the disruption of the blood-brain barrier,among which the abnormal activation of the JAK2/STAT3 signaling pathway is the key molecular mechanism.Studies have shown that acupuncture,through multi-target and holistic regulatory effects,can effectively down-regulate the level of the key pro-inflammatory factor IL-6,thereby inhibiting the excessive activation of the JAK2/STAT3 signaling pathway.The inhibition of this pathway alleviated neuroinflammatory responses,alleviated oxidative stress damage,protected the integrity of the blood-brain barrier,and ultimately promoted neuronal repair and the recovery of synaptic plasticity.This review provides a scientific mechanism explanation for acupuncture treatment of PSCI and also offers a theoretical basis for the development of new strategies for PSCI treatment targeting the JAK2/STAT3 signaling pathway.Future research needs to further clarify the specific molecular mechanism by which acupuncture regulates this pathway and conduct high-quality clinical studies to verify its efficacy.