肠道微生物与支气管哮喘的相关性研究进展OA

Bronchial asthma is a common chronic respiratory disease that affects over 300 million people worldwide,seriously jeopardizing both physical and mental health and posing a significant burden on public health management.Currently,there is no definitive or curative treatment available.Numerous organs in the human body are colonized by a vast array of microorganisms,among which the gut microbiota is the most densely populated and diverse.The gut microbiota modulates the development and function of multiple systems throughout the body.With the rapid advances in omics and metabolomics technologies,the potential link between asthma and gut microbiota has attracted increasing research interest.Maintaining gut microbiota homeostasis may emerge as a novel target for precision medicine in asthma management.Therefore,this article reviews the latest evidence on the correlation and underlying immune mechanisms between gut microbiota and asthma in recent years,providing a comprehensive discussion to offer new insights for diagnostic and therapeutic strategies in the prevention,treatment,and long-term management of bronchial asthma.