HCG宫腔灌注对IVF-ET反复移植失败患者HRT-FET周期的影响研究OA

Objective:This study aims to evaluate the impact and safety of intrauterine perfusion of human chorionic gonadotropin(HCG)before embryo transfer in the frozen-thawed embryo transfer(FET)cycle with hormone replacement therapy(HRT)for endometrium preparation on the clinical outcomes of patients with repeated failed embryo transfer(RIF)in in vitro fertilization-embryo transfer(IVF-ET).Method:This study adopted a prospective randomized controlled design.A total of 140 patients who met the diagnostic criteria of RIF and were treated at Harbin Red Cross Central Hospital from January 2023 to May 2025 were selected as the study objects.All patients underwent endometrial preparation in the artificial cycle(HRT)protocol.By random grouping,70 patients were included in the perfusion group(with 500 U of HCG intrauterine perfusion the day before FET),and 70 patients were included in the control group(with 0.9%normal saline intrauterine perfusion at the same time).The primary observation indicator is the clinical pregnancy rate,and the secondary observation indicators include the biochemical pregnancy rate,embryo implantation rate,early miscarriage rate and ectopic pregnancy rate.Result:The clinical pregnancy rate,biochemical pregnancy rate,and embryo implantation rate of the perfusion group were significantly higher than those of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference between the two groups in terms of the early miscarriage rateand the ectopic pregnancy rate(P>0.05).Conclusion:For RIF patients in the HRT-FET cycle,intrauterine perfusion of HCG before transplantation is an intervention measure that can effectively increase the clinical pregnancy rate,biochemical pregnancy rate and embryo implantation rate,without increasing the risk of early miscarriage and ectopic pregnancy.It has good clinical application safety.