前庭毛细胞发育分化及再生中的基因调控和基因治疗研究进展OA

Vestibular hair cells are core vestibular sensory cells in the inner ear,responsible for detecting head acceleration,regulating body posture and facilitating coordinated movement.Damage or loss of vestibular hair cells is a main pathological basis for various vestibular diseases.Vestibular hair cells in mammals are not capable to regenerate spontaneously.Studies have shown that vestibular hair cell regeneration can be induced through targeted genetic regulation and gene therapy.This article focuses on the precise regulatory mechanisms by key genes that affect the development,differentiation,and regeneration of vestibular hair cells,and discusses the synergistic roles of key signaling pathways such as Notch,Wnt,and fibroblast growth factor in this process.Gene therapy,which delivers key genes to target cells via viral vectors,can effectively promote vestibular hair cell regeneration and function recovery.Future research will further explore the optimal strategies,timing,and long-term stability of gene therapy,aiming to pave new ways for developing methods for targeted treatment of vestibular dysfunction.