中耳胆脂瘤上皮组织BAG-1表达与病变侵袭程度及鼓室成形术后残留、复发的相关性分析OA

Objective To investigate the association between BAG-1 expression in middle ear cholesteatoma epithelial tissue and the extent of lesion invasion,as well as postoperative residual and recurrent disease following tympanoplasty.Methods A total of 125 patients with middle ear cholesteatoma treated at our hospital between October 1,2022 and May 1,2024 were included.Based on ossicular chain destruction,16 patients were classified as grade 0,29 as grade 1,31 as grade 2,and 49 as grade 3.According to the STAM staging system,42 patients were stageⅠ,58 stageⅡ,and 25 stage Ⅲ.Thirty patients experienced postoperative residual or recurrent disease.An additional 125 patients treated during the same period for non-cholesteatoma ear conditions(e.g.trauma,malformation,infection)served as the control group.Compare the differences in BAG-1 expression among the observation group with different degrees of ossicular destruction,different infiltration conditions,and different postoperative residuals and recurrences.Results BAG-1 expression was significantly elevated in the cholesteatoma group compared with the control group(P<0.05).BAG-1 levels progressively increased with greater ossicular chain destruction and deeper lesion infiltration(P<0.05).Patients without residual or recurrent lesions exhibited markedly lower BAG-1 optical density value than those with residual or recurrent disease(P<0.05).BAG-1 expression showed a significant positive correlation with both the extent of cholesteatoma invasion and postoperative residual/recurrent lesions(P<0.05).Conclusions BAG-1 expression in middle ear cholesteatoma epithelial tissue is positively associated with lesion invasiveness and postoperative residual or recurrent disease after tympanoplasty.These findings suggest that it may serve as valuable biomarker for assessing disease severity and predicting postoperative outcomes in cholesteatoma.