基于英国生物银行数据的人工耳蜗植入横断面研究OA

Objective To evaluate the impact of cochlear implantation(CI)on non-auditory outcomes,including tinnitus,sleep,and mental health,among individuals with hearing loss.Methods Using data from the UK Biobank(UKB),we identified cochlear implants users(CI group,n=197)and hearing-impaired individuals who met the candidacy criteria for implantation but had not received an implant(candidate group,n=668).In this cross-sectional analysis,we compared baseline characteristics,tinnitus,sleep difficulties and mental health indicators between groups.Missing data were addressed through multiple imputation.Multivariable logistic regression and propensity score matching(1:1)were applied to adjust for confounding by sex and age,and to examine association between CI implantation use and health outcomes.Results After adjusting for sex and age,CI users demonstrated significantly lower neuroticism scores(adjusted OR=0.56,95%CI:0.38～0.81,P=0.002)and a lower risk of insomnia(adjusted OR=0.65,95%CI:0.44～0.94,P=0.024)compared candidates.No significant associations with CI use were observed for tinnitus,sleep duration,depressive episodes,anxiety disorders,etc.Propensity score matching analysis confirmed the association between CI use and lower neuroticism(OR=0.63,95%CI:0.40～0.99,P=0.044),while the association with insomnia was no longer significant.Conclusions This study suggests that cochlear implantation may be associated with improved emotional stability and sleep quality,although no consistent associations were found for tinnitus or clinically diagnosed mood disorders.These findings indicate that the benefits of CI may extend beyond auditory restoration to certain dimensions of mental well-being.Prospective studies are needed to verify causal effects.