金石清瘟解毒口服液解热镇痛、止咳和化痰平喘药效学实验研究OA

Objective:To investigate the antipyretic,analgesic,antitussive,expectorant,and anti-asthmatic effects of Jinshi Qingwen Jiedu Oral Liquid.Methods:The antipyretic effect was evaluated using a rat fever model induced by 2,4-dinitrophenol.The analgesic effect was assessed via the hot plate test and acetic acid-induced writhing test in mice.The antitussive effect was observed using an ammonia water-induced cough model in mice.The expectorant effect was studied by measuring phenol red secretion in the tracheal segment of mice.The anti-asthmatic effect was examined using an acetylcholine-induced asthma model in guinea pigs.Results:Jinshi Qingwen Jiedu Oral Liquid significantly reduced body temperature in febrile rats,demonstrating an antipyretic effect.It prolonged the pain threshold in the hot plate test and reduced the number of writhes induced by acetic acid,indicating an analgesic effect.The preparation extended the cough latency and reduced cough frequency,confirming its antitussive property.It increased phenol red secretion in the trachea,revealing an expectorant effect.Additionally,it prolonged the asthma induction latency,demonstrating an anti-asthmatic effect.Conclusion:Jinshi Qingwen Jiedu Oral Liquid exhibits antipyretic,analgesic,antitussive,expectorant,and anti-asthmatic properties.