儿童哮喘中的特异性免疫治疗研究现状OA

By searching databases such as PubMed and CNKI,the clinical studies,meta-analyses and mechanistic studies on asthma-specific immunotherapy for children in recent years are screened,and the research progress in major interventions such as biologics and allergen-specific immunotherapy(AIT)is summarized and evaluated.Specific immunotherapy has shown some clinical potential in childhood asthma.Biologics can significantly reduce the rate of acute attacks and improve lung function in children with severe asthma;AIT has long-term efficacy in children with allergic asthma,but individual responses vary greatly.Cell therapies,such as regulatory T cell infusions,are in the experimental stage but have significant potential.Bacterial lysates may enhance immunomodulation by modulating the microbiota,but the mechanism needs to be further verified.Specific immunotherapy is still an important means in the treatment of asthma in children,and different strategies have their own advantages;individualized therapy and combined multi-target intervention need to be involved to improve the efficacy in the future.The results of this study provide a theoretical basis for further optimizing immunotherapy strategies for childhood asthma.