基于多系统的阻塞性睡眠呼吸暂停低通气综合征代谢组学研究进展OA
Advances in metabolomics research on obstructive sleep apnea-hypopnea syndrome based on multiple systems
阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)是多种原因引起呼吸暂停和通气不足,进而致使机体出现一系列病理生理改变的临床综合征.目前,OSAHS已被广泛认定为一种全身性疾病,且其发病率呈逐年攀升趋势,给社会带来了沉重的负担.代谢组学技术的蓬勃发展,为 OSAHS的研究带来了全新的契机.此种技术能够全面检测生物样本中小分子代谢物的动态变化,精准反映机体的代谢全貌.本研究探讨了 OSAHS在多系统中的特征性代谢改变,为筛选早期诊断标志物、制定精准治疗策略提供思路,并推动成果向临床转化,提升 OSAHS诊疗水平.
Obstructive sleep apnea-hypopnea syndrome(OSAHS)is a clinical syndrome that causes apnea and hypopnea due to various reasons,which in turn leads to a series of pathophysiological changes in the body.Currently,OSAHS has been widely recognized as a systemic disease,and its incidence rate is increasing year by year,imposing a heavy burden on society.The vigorous development of metabolomics technology has brought a new opportunity for the study of OSAHS.This technology can comprehensively detect the dynamic changes of small molecule metabolites in biological samples and accurately reflect the whole metabolic picture of the body.This article focuses on the characteristic metabolic changes of OSAHS in multiple systems,providing ideas for screening early diagnostic markers,formulating precise treatment strategies,and promoting the translation of results into clinical practice to improve the diagnosis and treatment of OSAHS.
万贻麟;石雪峰
青海大学,青海 西宁 810016青海省人民医院呼吸与危重症医学科,青海 西宁 810007
阻塞性睡眠呼吸暂停低通气综合征代谢组学代谢物
Obstructive sleep apnea-hypopnea syndromeMetabolomicsMetabolites
《中国医学前沿杂志（电子版）》 2026 (2)
93-101,9
The First Cohort of"National Outstanding Young Physicians"Awarded by the National Health Commission of the People's Republic of China(2024.41) 国家卫生健康委员会第一届"国家优秀青年医师"(国卫人发[2024]41号)
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