含兰索拉唑四联方案与含奥美拉唑四联方案用于老年慢性萎缩性胃炎的疗效对比OA
Comparison of effects of lansoprazole-containing quadruplet regimen and omeprazole-containing quadruplet regimen for chronic atrophic gastritis
目的 对比含兰索拉唑四联方案与含奥美拉唑四联方案治疗老年慢性萎缩性胃炎的疗效.方法 选取2023年6月至2024年12月安阳市人民医院收治的120例老年慢性萎缩性胃炎患者进行回顾性分析,根据治疗方案将所有患者分为对照组和研究组,每组60例.对照组采用含奥美拉唑四联方案治疗,研究组给予含兰索拉唑四联方案治疗,两组均治疗两周.对比两组患者治疗效果、幽门螺杆菌(Hp)根除率,治疗前后胃肠激素及炎症因子水平,以及不良反应发生情况.结果 研究组患者临床总有效率、Hp根除率分别为95.00%、93.33%,高于对照组(76.67%、78.33%)(χ2=8.292、5.551,均P<0.05);治疗后两组患者各项胃肠激素指标水平均较治疗前改善,且研究组改善更明显(t=19.376、6.428,均P<0.05);治疗后两组患者各项炎症因子指标水平均比治疗前下降,且研究组低于对照组(t=25.460、9.755、13.202、8.092,均P<0.05);两组患者不良反应总发生率对比,差异无统计学意义(χ2=2.157,P>0.05).结论 在对老年慢性萎缩性胃炎患者的治疗中,采用含兰索拉唑四联方案治疗可提升Hp根除率,改善胃肠激素指标,减轻炎症反应,且未显著增加不良反应发生风险,疗效确切.
[Objective]To compare the efficacy of the quadruple regimen containing lansoprazole and the quadruple regimen containing omeprazole in the treatment of chronic atrophic gastritis.[Methods]A total of 120 patients with chronic atrophic gastritis were included in this study,all from Anyang People's Hospital.The selection period was from June 2023 to December 2024 for retrospective analysis.All patients were divided into the control group(60 cases,treated with a quadruple regimen containing omeprazole)and the study group(60 cases,treated with a quadruple regimen containing lansoprazole)according to the treatment plan.All patients were treated for 2 weeks.The therapeutic effects,eradication rate of Helicobacter pylori(Hp),gastrointestinal hormone indicators before and after treatment,inflammatory factor levels,and occurrence of adverse reactions of the two groups of patients were compared.[Results]The total clinical effective rate and Hp eradication rate of the patients in the study group were 95.00%and 93.33%,respectively,which were higher than 76.67%and 78.33%of the control group(χ2=8.292,5.551;both P<0.05).After treatment,the levels of various gastrointestinal hormone indicators in both groups of patients improved compared with those before treatment,and the study group showed significant improvement(t=19.376,6.428;both P<0.05).After treatment,various inflammatory factor levels in both groups decreased compared with those before treatment,and those in the study group were even lower(t=25.460,9.755,13.202,8.092,all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups of patients(χ2=2.157,P>0.05).[Conclusion]In the treatment of elderly patients with chronic atrophic gastritis,the quadruple regimen containing lansoprazole can increase the eradication rate of Hp,improve gastrointestinal hormone indicators,reduce inflammatory responses,and does not increase the occurrence of adverse reactions,with definite therapeutic effects.
赵晨;李丹微
河南省安阳市人民医院 药学部,河南 安阳 455000河南省安阳市人民医院 药学部,河南 安阳 455000
医药卫生
慢性萎缩性胃炎兰索拉唑奥美拉唑效果
chronic atrophic gastritislansoprazoleomeprazoleeffect
《中国医学工程》 2026 (3)
87-91,5
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