钼靶X线摄影联合血清糖类抗原153、CYFRA21-1水平检测对早期乳腺癌的诊断价值分析OA
Diagnostic value of mammography combined with serum carbohydrate antigen 153 and CYFRA21-1 level detection for early breast cancer
目的 探讨钼靶X线摄影联合血清糖类抗原153(CA153)、细胞角质蛋白19片段(CYFRA21-1)水平检测对早期乳腺癌的诊断价值.方法 采用回顾性分析方法,收集2024年1月至2025年1月三门峡市中心医院147例乳腺癌疑似病例作为研究样本,依据病理诊断结果,将研究对象分为恶性组(94例)、良性组(53例).分析乳腺癌患者钼靶X线摄影的影像学特征,比较两组血清CA153、CYFRA21-1水平,分析钼靶X线摄影、血清CA153、CYFRA21-1水平单独及联合对早期乳腺癌的诊断效能.结果 乳腺癌直接征象中,有61例钙化、8例结构紊乱、77例肿块,间接征象中,有59例星芒征、13例乳腺导管异常、18例恶性晕圈、17例乳腺血管异常、局部皮肤增厚或收缩1例、3例乳头回缩;与良性组相比,恶性组血清CA153、CYFRA21-1水平较高(P<0.05);恶性组钙化肿块、星芒征、恶性晕圈、血管增粗发生率高于良性组(P<0.05);钼靶X线摄影、血清CA153、CYFRA21-1水平单独诊断结果与病理检查结果呈现中度一致性(Kappa值=0.607、0.603、0.597),各指标联合诊断结果与病理检查结果呈现高度一致性(Kappa值=0.783);钼靶X线摄影联合血清CA153、CYFRA21-1水平检测对乳腺癌诊断的曲线下面积(AUC)值高于单项检测,差异有统计学意义(P<0.05).结论 钼靶X线摄影、血清CA153、CYFRA21-1水平均对早期乳腺癌有一定诊断价值,各指标联合可为临床诊断乳腺癌提供更高价值参考,并为后续治疗方案的制定提供指导.
[Objective]To explore the diagnostic value of mammography combined with serum carbohydrate antigen 153(CA153)and cytokeratin 19 fragment(CYFRA21-1)levels for early breast cancer.[Methods]A retrospective analysis method was used,147 suspected cases of breast cancer were collected from Sanmenxia Central Hospital between January 2024 and January 2025 as research samples.Based on the pathological diagnosis results,the subjects were divided into a malignant group(94 cases)and a benign group(53 cases).The imaging characteristics of mammography in breast cancer patients were analyzed,and the levels of serum CA153 and CYFRA21-1 were compared between the two groups.The diagnostic efficacy of mammography,serum CA153,and CYFRA21-1 levels,both individually and in combination,for early breast cancer was analyzed.[Results]Among the direct signs of breast cancer,there were 61 cases of calcification,8 cases of structural disorder,77 cases of mass.Among the indirect signs,there were 59 cases of star sign,13 cases of breast duct abnormality,18 cases of malignant halo,17 cases of breast vascular abnormality,1 case of local skin thickening or contraction,and 3 cases of nipple retraction.Compared with the benign group,the malignant group had higher levels of serum CA153 and CYFRA21-1,and the differences were statistically significant(P<0.05).The incidence of calcified masses,stellate sign,malignant halo,and vascular thickening in the malignant group was significantly higher than that in the benign group,with the difference being statistically significant(P<0.05).The individual diagnostic results of mammography,serum CA153,and CYFRA21-1 levels showed moderate consistency with pathological examination results(Kappa values=0.607,0.603,0.597),while the combined diagnostic results of various indicators showed high consistency with pathological examination results(Kappa value=0.783).The area under the reciever operating characteristic curve(AUC)value of the combination of mammography and serum CA153,CYFRA21-1 level detection for breast cancer diagnosis was higher than that of single detection,and the difference was statistically significant(P<0.05).[Conclusion]Mammography,serum CA153,and CYFRA21-1 levels all have certain diagnostic value for early breast cancer.The combination of these indicators can provide a higher value reference for clinical diagnosis of breast cancer and guide the formulation of subsequent treatment plans.
杨露露;杨小龙;张毅繁
三门峡市中心医院 普通放射诊断中心,河南 三门峡 472000三门峡市中心医院 普通放射诊断中心,河南 三门峡 472000三门峡市中心医院 医学检验科,河南 三门峡 472000
医药卫生
乳腺癌早期钼靶X线摄影糖类抗原153CYFRA21-1诊断
breast cancerearly stagemammographycarbohydrate antigen 153CYFRA21-1diagnosis
《中国医学工程》 2026 (3)
49-54,6
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