HIF-1α调控铁死亡在继发性脊髓损伤中的作用机制研究进展OA
Research progress in roles and mechanisms of HIF-1α-regulated ferroptosis in secondary spinal cord injury
脊髓损伤是一种严重的中枢神经系统创伤性疾病,其复杂的病理生理过程(尤其是继发性损伤)给临床治疗带来巨大挑战.研究证实,铁死亡作为铁依赖且以脂质过氧化为核心特征的新型程序性细胞死亡方式,是调控继发性脊髓损伤的关键环节,而低氧诱导因子1α(HIF-1α)作为细胞应对缺氧环境的核心转录因子,可通过调控铁代谢稳态、氧化应激及炎症信号通路等途径,影响 脊髓损伤发生发展与神经功能恢复.本文系统综述脊髓损伤病理生理过程、脊髓损伤中铁死亡机制和HIF-1α在脊髓损伤中作用与调控机制,并总结HIF-1α调控脊髓损伤后铁死亡过程的潜在作用,以期为脊髓损伤治疗提供理论依据和干预思路.
Spinal cord injury(SCI)is a severe traumatic disease of the central nervous system.Its complex pathophysiological processes,especially secondary injury,pose a major challenge to clinical treatment.Ferroptosis,a form of programmed cell death characterized by iron-dependent lipid peroxida-tion,has been recognized as an important mechanism in secondary spinal cord injury.Hypoxia-induc-ible factor-1α(HIF-1α),a key transcription factor involved in the cellular response to hypoxia,regulates iron metabolism,oxidative stress,and inflammatory signaling pathways,thereby influencing the pro-gression of SCI and neurological recovery.This review summarizes the pathophysiological processes of SCI,mechanisms of ferroptosis,and regulatory roles of HIF-1α.In addition,the potential involvement of HIF-1α in ferroptosis after SCI is explored in order to offer new lines of thought for potential therapeu-tic strategies.
李雪;阎新龙
北京工业大学化学与生命科学学院,北京 100124北京工业大学化学与生命科学学院,北京 100124
医药卫生
脊髓损伤铁死亡低氧诱导因子1α氧化应激铁代谢继发性损伤
spinal cord injuryferroptosishypoxia-inducible factor-1αoxidative stressiron metabolismsecondary injury
《中国药理学与毒理学杂志》 2026 (2)
152-160,9
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