学龄期儿童配戴多元透镜分区离焦镜片后眼轴和屈光度变化的对照研究OA

Objective To investigate the differences in axial length and refractive error changes between school-age children wearing a Diversified Segmental Defocus Optimization(DSDO)lens and those using conventional optical correc-tion,across different baseline refractive groups.Methods This prospective non-randomized controlled study enrolled school-age children with a spherical equivalent(SE)ranging from-2.00D to+2.00D.Based on participant and parental preference,children were assigned to either the control group(physiological hyperopes without correction or low myopes wearing single-vision spectacles)or the experimental group(wearing the DSDO lens).According to cycloplegic retinos-copy results,participants were stratified into three refractive subgroups:1)Low hyperopia:+0.75D＜SE≤+2.00D;2)Pre-myopia:-0.50D＜SE≤+0.75D;3)Low myopia:-2.00D≤SE≤-0.50D.Follow-up examinations were con-ducted at 6 and 12 months after enrollment.Primary outcome measures included axial length(AL),SE,choroidal thick-ness(CHT),and choroidal vascularity index(CVI).Results A total of 113 participants completed the 12-month follow-up(attrition rate:3.4％).Axial elongation was significantly lower in all experimental subgroups compared to their respective control subgroups:low hyperopia(0.12±0.11 mm vs.0.21±0.09 mm;P=0.0003;Cohen's d=0.90),pre-myopia(0.18±0.19 mm vs.0.38±0.18 mm;P＜0.0001;d=1.08),and low myopia(0.22±0.22 mm vs.0.51±0.20 mm;P＜0.0001;d=1.36).Changes in SE followed a similar trend to AL.At the 6-month follow-up,CHT in all measured sectors was significantly thicker in the pre-myopia and low myopia experimental subgroups compared to controls.At 12 months,these differences persisted in most sectors for the pre-myopia subgroup and in all sectors for the low myopia subgroup.Significant CVI changes were primarily observed in the low hyperopia subgroup.Conclusions Wearing DSDO lenses was associated with slower axial elongation and myopia progression compared with conventional correction.