腹腔镜下保留十二指肠胰头切除术术前胆道支架植入临床效果研究OA
Study on the clinical effect of biliary stent implantation before laparoscopic duodenum-preserving pancreatic head resection
目的 评估腹腔镜下保留十二指肠胰头切除术(LDPPHR)术前经内镜逆行胰胆管造影(ERCP)置入胆道支架的临床效果与安全性.方法 回顾性分析2021年1月至2024年1月云南省第三人民医院收治的36例行LDPPHR病人的临床资料.根据术前是否经ERCP放置胆道支架,将病人分为支架组(19例)和非支架组(17例).对比分析两组病人的手术时间、术中出血量、术后住院时间等围手术期指标,以及术后胰瘘、胆瘘、出血、胃排空延迟、胆管狭窄伴胆管结石等并发症发生率和再次手术率.结果 36例病人均顺利完成手术,无中转开腹.支架组与非架组病人手术时间[220.00(190.00,240.00)min vs.237.50(200.00,272.25)min,P=0.285]、术中出血量[100.00(100.00,200.00)mL vs.100.00(50.00,275.00)mL,P=0.806]、术后住院时间[21.00(19.00,25.00)d vs.24.50(22.00,27.75)d,P=0.034]比较,差异均无统计学意义(P>0.05).两组病人术后胰瘘、胆瘘、出血、胃排空延迟、胆管狭窄伴结石发生率及再次手术率比较,差异亦无统计学意义(P>0.05).但在具体并发症发生情况上,支架组胆瘘发生率(5.3%vs.17.6%)与再次手术率(0vs.17.6%)低于非支架组绝对值;在并发症处理方面,非支架组多例胆瘘需后期置入支架治愈,且有1例因内镜取石失败被迫行外科胆肠吻合术,而支架组并发症均经保守或内镜干预成功治愈.结论 术前经ERCP预防性置入胆道支架应用于LDPPHR安全、可行,未增加手术时间与出血量.预先置入胆道支架有助于术中提供直观导航以保护胆总管,虽受限于样本量未能显示出显著降低并发症发生率的统计学差异,但在一定程度上简化了术后胆瘘及胆管狭窄等并发症的后续处理流程,可作为LDPPHR围手术期并发症管理的一种有效辅助手段.
Objective To evaluate the clinical efficacy and safety of preoperative biliary stenting via endoscopic retrograde cholangiopancreatography(ERCP)in laparoscopic duodenum-preserving pancreatic head resection(LDPPHR).Methods The clinical data of 36 patients who underwent LDPPHR at the Third People's Hospital of Yunnan Province between January 2021 and January 2024 were retrospectively analyzed.According to whether preoperative biliary stenting was performed via ERCP,the patients were divided into the stent group(19 cases)and the non-stent group(17 cases).Perioperative indicators,such as operative time,intraoperative blood loss,and postoperative hospital stay,the incidences of postoperative complications including pancreatic fistula,biliary fistula,hemorrhage,delayed gastric emptying,and biliary stricture with bile duct stones,and the reoperation rate were compared and analyzed between the two groups.Results All 36 patients successfully underwent the surgery without conversion to open surgery.There were no statistically significant differences between the stent group and the non-stent group in operative time[220.00(190.00,240.00)min vs.237.50(200.00,272.25)min],intraoperative blood loss[100.00(100.00,200.00)mL vs.100.00(50.00,275.00)mL,P=0.806],and postoperative hospital stay[21.00(19.00,25.00)d vs.24.50(22.00,27.75)d](all P>0.05).The differences in the incidences of postoperative pancreatic fistula,biliary fistula,hemorrhage,delayed gastric emptying,biliary stricture with stones,and the reoperation rate between the two groups were also not statistically significant(all P>0.05).However,regarding specific complications,the absolute values of the incidence of biliary fistula(5.3%vs.17.6%)and the reoperation rate(0 vs.17.6%)in the stent group were lower than those in the non-stent group.In terms of complication management,multiple cases of biliary fistula in the non-stent group required later stenting for cure,and 1 case was forced to undergo surgical bilioenteric anastomosis due to the failure of endoscopic stone extraction,whereas all complications in the stent group were successfully cured by conservative or endoscopic interventions.Conclusion Preoperative prophylactic biliary stenting via ERCP is safe and feasible for LDPPHR,without increasing operative time and blood loss.Pre-stenting helps provide intuitive navigation during surgery to protect the common bile duct.Although it fails to show a statistically significant difference in reducing the incidence of complications limited by the sample size,it simplifies the subsequent management process of complications such as postoperative biliary fistula and biliary stricture to a certain extent,and can serve as an effective adjunct for the perioperative complication management of LDPPHR.
李伟;李胜宏;曹安菊;赵丽萍;钟国平;范成虎;江行
云南省第三人民医院肝胆胰外科,云南 昆明 650000云南省第三人民医院肝胆胰外科,云南 昆明 650000云南省第三人民医院肝胆胰外科,云南 昆明 650000云南省第三人民医院肝胆胰外科,云南 昆明 650000云南省第三人民医院肝胆胰外科,云南 昆明 650000云南省第三人民医院肝胆胰外科,云南 昆明 650000云南省第三人民医院肝胆胰外科,云南 昆明 650000
医药卫生
腹腔镜下保留十二指肠胰头切除术内镜逆行胰胆管造影胆道支架手术并发症
laparoscopic duodenum-preserving pancreatic head resectionendoscopic retrograde cholangiopancreatog-raphybiliary stentsurgical complications
《中国实用外科杂志》 2026 (3)
381-387,7
兴滇英才支持计划项目(No.2023MY007) Yunnan Xingdian Talent Support Program(No.2023MY007)
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