耳穴疗法通过调控神经生物学缓解卒中后抑郁的机制研究进展OA
Research progress on the mechanism by which auricular therapy alleviates post-stroke depression through regulating neurobiology
卒中后抑郁(PSD)是卒中后最常见的精神并发症,严重影响患者神经功能恢复与生活质量.当前抗抑郁药物虽为一线治疗方案,但存在心脏毒性、胃肠道反应及成本较高等局限.耳穴疗法作为融合中医学与现代神经解剖学的非药物干预手段,通过多靶点调控机制在PSD治疗中显示出独特优势.本文基于神经生物学与中医理论双重视角,系统综述耳穴疗法干预PSD的作用机制,主要包括:(1)调节单胺类与氨基酸类神经递质稳态;(2)促进神经可塑性与脑网络功能重组;(3)抑制神经炎症与氧化应激反应;(4)调节神经内分泌系统.旨在全面阐释耳穴疗法通过"神经-免疫-内分泌"多维调控网络缓解PSD的作用机制,推动耳穴疗法在PSD治疗中的进一步研究与应用.
Post-stroke depression(PSD)is the most common mental complication after stroke,seriously affecting recovery of neurological function and quality of life.Although antidepressants are currently the first-line treatment,they have limitations such as cardiotoxicity,gastrointestinal reactions,and relatively high costs.As a non-pharmaceutical intervention method integrating traditional Chinese medicine and modern neuroanatomy,auricular therapy has shown unique advantages in PSD treatment through a multi-target regulatory mechanism.From the perspective of neurobiology,this article systematically reviews the mechanism of auricular therapy in PSD intervention,including:(1)the regulation of monoamine and amino acid neurotransmitter homeostasis;(2)promoting neural plasticity and the reorganization of brain network functions;(3)inhibiting neuroinflammation and oxidative stress responses;(4)and regulating the neuroendocrine system.This review aims to comprehensively explain the mechanism by which auricular therapy alleviates PSD through a multidimensional neuro-immune-endocrine regulatory network to promote further research and application in PSD treatment.
先容;杨智鹏;王超;王甜;林征玉;刘海静
云南中医药大学第二临床医学院,昆明 650500云南中医药大学第一临床医学院,昆明 650500云南中医药大学第一临床医学院,昆明 650500云南中医药大学第二临床医学院,昆明 650500云南中医药大学第二临床医学院,昆明 650500云南中医药大学第二临床医学院,昆明 650500
医药卫生
耳穴疗法卒中后抑郁神经生物学机制
auricular therapypost-stroke depressionneurobiologymechanism
《中国比较医学杂志》 2026 (7)
114-124,11
云南省科技厅科技计划项目(202401AZ070001-018,202405AS350007).
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