中医药调控T淋巴细胞治疗干燥综合征的研究进展OA

Sjögren's syndrome(SS)is a chronic autoimmune disease that usually occurs because of immune system disorders;however,the specific mechanism is still unclear,and there is no cure.T lymphocytes are an important type of immune cell;their role in SS occurrence and development has been widely described,and they are an important target for anti-SS treatment.Although modern medical treatment can alleviate symptoms and delay progression to some extent,there are obvious clinical limitations.Additionally,the overall treatment effect is not satisfactory,making it important to find an effective and safe treatment method.Traditional Chinese medicine treats diseases based on the fundamental principles of syndrome differentiation and holistic concepts;it has been found to have multi-pathway,multilevel,and multi-target anti-SS effects.Active ingredients of traditional Chinese medicine,such as Fangchinoline,total glucosides of paeony,and Salidroside,as well as traditional Chinese medicine compound prescriptions such as Moisturizing and Drying Formula,Yangyin Yiqi Huoxue Formula,and Jiefu Huaxue Shengjing Formula,can regulate the changes of different T lymphocyte subsets through signaling pathways such as PI3K/AKT/mTOR,STAT3,and NF-κB.These treatments synergistically alleviate inflammatory responses,reduce immune infiltration,and improve glandular function to achieve a therapeutic effect in SS.This article reviews and analyzes the relevant recent research on traditional Chinese medicine treatments for SS,and discusses their mechanisms in regulating T lymphocytes against SS to provide new ideas for the clinical treatment of this condition.