血液筛查反应性献血者管理专家共识OA

Blood screening is an essential step to ensure blood safety by reducing the risk of transfusion-transmitted in-fectious.Due to the increasing number of viral markers targeted and the use of assays with highly analytical sensitivity,the effectiveness of blood screening has improved significantly.However,the loss of qualified blood donors due to false positive results has attracted widespread concern.With the continuous development of detection methods,laboratory technical speci-fications and diagnostic guidelines for infections caused by blood-borne pathogens have also been constantly updated.The consensus recommendations proposed here systematically elaborates on key elements of markers and detection of pathogens transmitted through transfusion,confirmation of infection,and donor deferral criteria.Relevant national and international studies on blood screening,as well as previously published guidelines,standards and consensus statements,and the current situation in China,are also taken into consideration.The level of evidence and the quality of recommendations are scientifi-cally evaluated using the GRADE framework(Grading of Recommendations,Assessment,Development,and Evaluation).The consensus aims to ensure transfusion safety by permanently excluding infected individuals,while preserving the rights and interests of blood donors by maintaining the eligibility assessment of individuals who are not infected or whose infection is not confirmed,thereby reducing donor loss.