尿酸与高密度脂蛋白胆固醇比值与代谢综合征的关系研究:基于云南省彝族人群OA

Background Metabolic syndrome(MetS)is a global public health issue,with an increasing prevalence among the Yi ethnic group due to their unique lifestyle and genetic background.The uric acid(UA)to high-density lipoprotein cholesterol(HDL-C)ratio(UHR)is closely related to various metabolic diseases and requires further investigation.Objective This study aims to explore the association between UHR and MetS in the Yi ethnic group of Yunnan Province,and to assess the predictive value of UHR for the risk of MetS.Methods From May to November 2021,a stratified cluster sampling method was employed to select 1 100 Yi ethnic residents from 17 villages across 6 sample streets/towns in Anning City,Yunnan Province.After excluding 49 ineligible cases,a total of 1 051 subjects were ultimately included in the study.General demographic data and physical examination indicators were collected from all participants.The UHR was calculated,and Pearson correlation analysis along with Binary Logistic regression analysis were performed to examine the association between UHR and MetS.Additionally,the receiver operating characteristic(ROC)curve analysis was conducted to evaluate the predictive value of UHR for the risk of MetS.Results Among the 1 051 participants,there were 335(31.87%)males and 716(68.13%)females,with a mean age of(70±7)years.The study identified 235(22.36%)cases of MetS and 816(77.64%)non-MetS cases.Significant differences were observed between MetS and non-MetS groups in age,BMI,systolic blood pressure(SBP),diastolic blood pressure(DBP),triglycerides(TG),total cholesterol(TC),HDL-C,low-density lipoprotein cholesterol(LDL-C),alanine aminotransferase(ALT),aspartate aminotransferase(AST),UA,fasting blood glucose(FBG)and UHR levels(P<0.05).The UHR was significantly higher in the MetS group(P<0.05).Participants were stratified into quartiles(Q1-Q4)based on UHR levels(7.94%,10.57%,and 14.75%as cut-off points).Cochran-Armitage trend test revealed a significant dose-dependent increase in the prevalence of MetS and its components with ascending UHR quartiles(P<0.001).Pearson correlation analysis demonstrated positive associations of UHR with age,height,body weight,BMI,waist circumference(WC),SBP,DBP,creatinine(Cr),urea,TG,FBG,ALT,and UA(P<0.05),while negative correlations were observed with TC,HDL-C,LDL-C,AST,and direct bilirubin(DBIL)(P<0.05).Binary Logistic regression analysis showed that the risk of MetS in the Q4 group was 27.31 times that of the Q1 group(95%CI=11.39-65.47,P<0.01).After adjusting for confounding variables,each 1-unit increase in UHR was associated with a 29%elevated risk of MetS(OR=1.29,95%CI=1.22-1.35,P<0.01).ROC curve analysis confirmed a strong predictive value of UHRfor MetS(AUC=0.805).Conclusion High UHR is a risk factor for MetS in Yi ethnic group and has a good predictive value for the risk of MetS.