视神经脊髓炎谱系疾病潜在生物标志物研究进展OA

Neuromyelitis optica spectrum disorder(NMOSD)is a demyelinating disease of central nervous system characterized by high recurrence rate and high disability rate.Biomarkers play an important role in the diagnosis,differential diagnosis,treatment and prognosis assessment of NMOSD,which can better help clinicians to diagnose NMOSD,distinguish it from multiple sclerosis(MS)and other demyelinating diseases of the central nervous system,and help doctors to evaluate the treatment effect and prognosis of the disease.Finding more potential biomarkers and tapping the application potential of the discovered biomarkers can not only further elucidate the pathogenesis of NMOSD,but also discover new therapeutic targets.This will help doctors develop better treatment plans,more accurately assess the risk and severity of disease recurrence,and reduce the recurrence and disability rate of NMOSD.This article reviewed the research progress of newly discovered NMOSD biomarkers with potential value in recent years,including lncRNA,complement components,markers of neuronal and astrocyte damage,granulocyte activation markers,AQP-4 antibody titers,and cytokines.