可诱导共刺激分子的作用机制及其在器官纤维化中的研究进展OA

Fibrosis is a common condition in chronic diseases,characterized by a reduction in parenchymal cell necrosis and an abnormal increase in extracellular matrix,leading to the destruction of organ structure and causing organ failure,the underlying mechanisms of its pathogenesis are currently unclear.Inducible costimulators(ICOS),members of the CD28 family,promote T cell proliferation,differentiation,and the release of various cytokines upon binding to their ligands,thus participating in the regulation of the body's immune response,who play a crucial role in various diseases,including tumor and rheumatoid arthritis.This paper focuses on the mechanisms of ICOS signal transduction and immunoregulation,as well as their role in organ fibrosis,providing a theoretical basis for a deeper understanding of the formation of fibrosis.