慢性炎症与皮肤衰老:机制解析及干预策略OA

As the outermost barrier of the body,the skin is one of the earliest organs to show changes during the aging process.In recent years,chronic inflammation has been officially listed as one of the core indicators of aging,and the skin is an important site where this inflammatory process occurs.This article systematically reviews the occurrence mechanism of chronic skin inflammation,including factors such as skin cell senescence and its secreted skin-Senescence-Associated Secretory Phenotype(skin-SASP),Skin barrier function impairment,DNA damage,oxidative stress,immunosenescence,microbiota imbalance,and macrophage activation,and clarifies how these factors activate inflammatory pathways,disrupt skin structure and function.Accelerate the aging process of the skin.In addition,this article also explores various intervention strategies from the perspective of anti-inflammation,such as a healthy lifestyle,Senolytics,and stem cell therapy,providing new theoretical basis and practical paths for delaying inflammatory skin aging.In the future,further in-depth research should be conducted on the dynamic change mechanism of skin inflammation to achieve a coordinated intervention of precise inflammation control and effective anti-aging.