iShim-DWI联合T1 mapping对甲状腺良恶性结节的诊断价值OA

Objective:To evaluate the value of iShim-DWI combined with T1 mapping in differentiating benign from ma-lignant thyroid nodules.Methods:A total of 56 patients(63 nodules)with thyroid nodules were collected consecutively and di-vided into benign group and malignant group.All patients underwent preoperative 3.0T MRI examinations,including conven-tional MRI,iShim-DWI(b=0,500,and 800 s/mm2),and pre-contrast T1 mapping.Apparent diffusion coefficient(ADC)values and pre-contrast T1 relaxation times were measured.Independent two-sample t-tests were used to compare ADC and T1 values between benign and malignant nodules.ROC curves were plotted to assess diagnostic performance.Results:The mean ADC value(b=800 s/mm2)was significantly higher in benign nodules than in malignant nodules:(1.399±0.359)×10-3 mm2/s vs.(1.052±0.295)×10-3 mm2/s(t=4.090,P＜0.001).The mean T1 value was significantly lower in benign nodules compared to malignant ones(1 443±228)ms vs.(1 661±206)ms(t=-3.824,P＜0.001).The AUC for ADC alone was 0.786,and for T1 alone was 0.769.The combined use of ADC and T1 values yielded an AUC of 0.897,significantly higher than either parameter alone.According to the DeLong test,the combined diagnostic model showed a statistically significant improvement(P＜0.05).The sensitivity and specificity of the combined model were 80.95%and 85.71%,respectively.Conclusion:The combination of iShim-DWI and T1 mapping provides significant advantages in differentiating benign and malignant thyroid nodules by non-invasively quantifying ADC and T1 values.This integrated quantitative method offers a novel,non-invasive framework for precision diagnosis of thy-roid nodules,demonstrating strong potential to optimize clinical decision-making.