基于mCTP的侧支循环量化评估与急性脑梗死体积及神经功能转归的关系OA

Objective:To investigate the relationship between collateral circulation quantified by multiphase CT perfusion(mCTP)and the infarct volume and neurological functional outcome in patients with acute cerebral infarction(ACI).Methods:A total of 138 ACI patients were divided into a collateral circulation group(n=76)and a non-collateral circulation group(n=62).The predictive performance of mCTP parameters for collateral circulation in ACI was evaluated using ROC curve analysis,while their correlation with infarct volume was assessed via Pearson correlation analysis.Multivariate Logistic regression was used to analyze the influencing factors of neurological outcome,and the predictive value of mCTP parameters for neurological outcomes was further analyzed using ROC curves.The predictive value of this pathway was evaluated using ROC curve anal-ysis.Results:The scores of NIHSS and mRS in the collateral circulation group were significantly lower than those in the non-collateral circulation group(P＜0.05).CBF and CBV in the collateral circulation group were significantly higher than those in the non-collateral circulation group(P＜0.05).TTP and MTT were significantly lower than those in the non-collateral circula-tion group(P＜0.05).The results of ROC analysis showed that CBF,CBV,TTP and MTT had good predictive value for the col-lateral circulation of ACI(P＜0.05),and the predictive value of combined detection was better than that of each index alone(P＜0.05).The results of Pearson correlation analysis showed that CBF and CBV were negatively correlated with the cerebral in-farction volume(P＜0.05),TTP and MTT were positively correlated with the cerebral infarction volume(P＜0.05).Univariate analy-sis showed that CBF and CBV in the good outcome group were significantly higher than those in the poor outcome group(P＜0.05),and TTP,MTT and mRS scores were significantly lower than those in the poor outcome group(P＜0.05).Multivariate Lo-gistic regression showed that CBF and CBV were independent protective factors for neurological function outcome(P＜0.05),and TTP and MTT were independent risk factors for neurological function outcome(P＜0.05)after adjusting for confounding factors such as mRS score,NIHSS score,and treatment plan.Conclusion:mCTP-based collateral circulation quantification can effec-tively reflect infarct volume and neurological functional outcome in ACI patients,providing an important basis for early diagno-sis,treatment decision-making,and prognosis evaluation in clinical practice.