基于低频振幅和局部一致性的遗尿症儿童认知功能障碍的静息态脑功能成像研究OA

Objective:To explore the relationship between ALFF and ReHo of whole brain voxels in resting-state brain functional imaging and the occurrence and development of cognitive dysfunction in children with enuresis.Methods:From June 2019 to June 2021,24 children with enuresis complicated with cognitive impairment(study group)and 24 healthy chil-dren(control group)were selected.The children in both groups were examined by MRI.The differences in resting-state brain function,ReHo,ALFF brain images and cognitive function were compared between two groups,and the correlation between imaging indexes and cognitive function was analyzed in all subjects.Results:The MMSE and MoCA scores of two groups had statistical significance,and the MMSE and MoCA scores of study group were obvious lower than control group(P＜0.05).The ALFF values of the left talus gyrus and the right talus gyrus in the study group were significantly lower than those in the control group(P＜0.05).The ReHo values of the left talus gyrus,left middle occipital gyrus,bilateral lingual gyrus,right wedge lobe,right fusiform gyrus and right superior occipital gyrus in the study group were significantly lower than those in the con-trol group(P＜0.05).Pearson correlation analysis in all 48 subjects showed that ALFF values in the left calcarine gyrus and the right calcarine gyrus were positively correlated with MMSE,and ReHo values in the left middle occipital gyrus and right su-perior occipital gyrus were positively correlated with MoCA(P＜0.05).Conclusion:The resting-state brain functional imaging abnormalities of the left talar gyrus,right talar gyrus,left middle occipital gyrus and right supraoccipital gyrus in children with enuresis are correlated with the occurrence and development of cognitive dysfunction.