microRNAs在帕金森病患者中表达谱的变化及诊疗潜力展望OA

Parkinson's disease(PD)is an age-as-sociated,slowly progressive extrapyramidal disor-der.Its prevalence is increasing annually in tandem with the aging population in China.The lack of high-ly specific biomarkers poses a significant challenge for the early diagnosis and treatment of PD.microR-NAs(miRNAs),a class of short non-coding RNA molecules,have been found to be dysregulated in the bodily fluids of PD patients and participate in PD pathological processes by regulating endogenous gene expression.The discovery of specific miRNAs expression profiles renders them attractive candi-dates as non-invasive biomarkers and novel thera-peutic targets.This review summarizes research on the relationship between miRNAs dysregulation and PD diagnosis and treatment.It elaborates on recent advancements concerning the roles of miRNAs in PD management by focusing on three key aspects:alterations in expression profiles,diagnostic value,and therapeutic potential.