慢性阻塞性肺疾病门诊患者的药物相关问题及其相关因素:一项横断面回顾性研究OA

AIM:Chronic obstructive pulmonary disease(COPD)is a globally prevalent condition,in-cluding a substantial patient population in China.However,data on drug-related problems(DRPs)among Chinese COPD outpatients remain scarce.This study aimed to investigate the types,causes,associated factors,and potential triggers of DRPs in COPD outpatients at a large general hospital in southern China.METHODS:With ethics committee approval,461 COPD patients prescribed at least one medication were enrolled in this retrospective study from September 2020 to November 2021.DRPs were identified and classified using the Pharmaceu-tical Care Network Europe(PCNE)DRP classification system(V9.10).Descriptive statistics,univariate analysis,and logistic regression were employed to explore potential risk factors for DRPs.RESULTS:A total of 239 DRPs with 567 underlying causes were identified.The most frequent DRP was"treatment effectiveness:insufficient effect"(91.2%,218/239).The leading causes were"no or inappropriate out-come monitoring"(31.0%,176/567)and"patient-related factors"(27.5%,156/567).Risk factors for DRPs included older age,current smoking,comor-bid bronchiectasis or silicosis,use of quinolone or lincosamide antibiotics,LABA+LAMA inhaler combi-nations,and a history of acute exacerbations.CONCLUSION:DRPs are common among Chinese COPD outpatients,primarily linked to suboptimal treatment effectiveness.Clinical pharmacists could play a crucial role in addressing these issues and im-plementing interventions in the future.