关节纤维化的病因、发病机制与临床诊疗进展OA

Arthrofibrosis is a pathological condition characterized by excessive fibrous tissue hyperplasia occurring in or around the joint due to various etiological factors,leading to impaired normal joint function.The exact patho-genesis of arthrofibrosis remains incompletely elucidated,encompassing complex processes such as cellular prolifer-ation,activation of fibrogenic signaling pathways,and extracellular matrix remodeling.These processes may be ini-tiated by multiple inciting factors,including trauma,chronic inflammation,immune stress,and metabolic disor-ders.Despite advancements in therapeutic approaches,clinical outcomes for arthrofibrosis remain suboptimal.This review systematically synthesized the major etiological factors,pathological mechanisms,and current treatment mo-dalities for arthrofibrosis,while also delineating future research directions and potential therapeutic strategies to en-hance both scientific research and clinical management of this condition.