血清eCIRP对老年脓毒症的诊断价值研究OA
Diagnostic value of serum eCIRP in sepsis in elderly patients
目的 探讨血清细胞外冷诱导 RNA 结合蛋白(eCIRP)对老年脓毒症的诊断价值.方法 采用横断面研究方法,选取 2022 年 8 月 1 日—12 月 31 日于四川省人民医院住院、年龄≥60 岁的老年感染性疾病患者,纳入同期老年非感染患者作为无感染组.依据 2016 年《第三版脓毒症与感染性休克定义国际共识》中的脓毒症诊断标准,将感染患者分为脓毒症组与非脓毒症组.收集患者的临床资料及血标本,比较三组患者的血清 eCIRP 浓度,应用受试者工作特征曲线下面积(AUC)评估 eCIRP 对老年脓毒症的诊断价值,应用 Delong 检验比较炎症指标间的AUC.结果 共纳入老年感染性疾病患者 109 例(脓毒症组 44 例,非脓毒症组 65 例),无感染组 42 例.与无感染组比较,非脓毒症组和脓毒症组患者血清 eCIRP 浓度均升高(均 P<0.001).与非脓毒症组比较,脓毒症组患者血清 eCIRP 浓度升高(P<0.001).eCIRP 联合中性粒细胞百分比(NEUT％)、C 反应蛋白(CRP)、降钙素原(PCT)检测诊断老年脓毒症的 ACU 为 0.963,高于单一指标 eCIRP(AUC=0.862)、NEUT％(AUC=0.855)、CRP(AUC=0.877)及 PCT(AUC=0.845),差异均有统计学意义(均 P<0.05).结论 eCIRP 对老年脓毒症具有诊断价值,是诊断脓毒症的重要生物标志物.联合检测 eCIRP 与 NEUT％、CRP、PCT 可显著提高老年脓毒症的诊断准确性.
Objective To explore the diagnostic value of serum extracellular cold-inducible RNA-binding protein(eCIRP)in sepsis in elderly patients.Methods Elderly patients(aged≥60 years old)with infectious diseases hospitalized in Sichuan Provincial People's Hospital from August 1 to December 31,2022 were selected for cross-sectional survey,and elderly patients without infection were included as the non-infection group.According to the diagnostic criteria for sepsis in"International consensus on the definition of sepsis and septic shock"(2016),infected patients were divided into a sepsis group and a non-sepsis group.Clinical data and blood specimens of patients were collected. Serum eCIRP concentrations of three groups of patients were compared. Diagnostic value of eCIRP for sepsis in elderly patients was evaluated with the area under the receiver operating characteristic curve (AUC). AUCs of inflammatory indicators were compared with Delong's test. Results A total of 109 elderly patients with infectious diseases (44 in the sepsis group, 65 in the non-sepsis group) and 42 patients in non-infection group were included in analysis. Compared with non-infection group, serum eCIRP concentrations in both the non-sepsis group and sepsis group increased (both P<0.001). Compared with the non-sepsis group, serum eCIRP con-centration in sepsis group increased (P <0.001 ). The ACU of eCIRP combined with neutrophil percentage (NEUT％), C-reactive protein (CRP), and procalcitonin (PCT) detection for the diagnosis of sepsis in elderly patients was 0.963, which was higher than the single indicators of eCIRP (AUC=0.862), NEUT％ (AUC= 0.855), CRP (AUC=0.877), and PCT (AUC=0.845), differences were all statistically significant (all P <0.05).Conclusion eCIRP has diagnostic value for sepsis in elderly patients and is an important biomarker for diag-nosis of sepsis.The combined detection of eCIRP with NEUT％,CRP,and PCT can significantly improve the ac-curacy in diagnosing sepsis in elderly patients.
陈梦纯;范真;赵盈颖;廖洋;何秋梅;郭姝瑾
成都中医药大学医学与生命科学学院老年医学科,四川 成都 610075四川省医学科学院·四川省人民医院老年医学中心,四川 成都 610072成都中医药大学医学与生命科学学院老年医学科,四川 成都 610075成都中医药大学医学与生命科学学院老年医学科,四川 成都 610075电子科技大学医学院临床医学,四川 成都 611731四川省医学科学院·四川省人民医院健康管理中心,四川 成都 610072
医药卫生
细胞外冷诱导RNA结合蛋白感染脓毒症老年人诊断价值
extracellular cold-inducible RNA-binding proteininfectionsepsiselderly persondiagnostic value
《中国感染控制杂志》 2026 (4)
545-551,7
四川省科技厅重点研发项目(2022YFS0108)四川省人民医院院基金(2021LY22)四川省干部保健课题(2021-205)
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