布托啡诺联合氟比洛芬酯在腹腔镜结肠癌根治术后的应用效果观察OA
Clinical Efficacy of Butorphanol Combined with Flurbiprofen Axetil for Postoperative Analgesia After Laparoscopic Radical Resection of Colon Cancer
目的:观察布托啡诺联合氟比洛芬酯在腹腔镜结肠癌根治术后的应用效果.方法:前瞻性选取2023年2月至2025年2月收治的68例腹腔镜结肠癌根治术患者为研究参与者,根据随机数字表法将患者分为对照组和观察组,每组34例.对照组患者使用氟比洛芬酯术后镇痛,观察组患者使用布托啡诺联合氟比洛芬酯术后镇痛,比较 2组患者在手术结束即刻(T1)、术后30 min(T2)、术后1 h(T3)、术后2 h(T4)、术后3 h(T5)、术后4 h(T6)的平均动脉压(MAP)和心率(HR),术后6 h、12 h、24 h、48 h的疼痛视觉模拟评分(VAS),2组患者进入恢复室后30 min的血气指标以及2组患者术后不良反应发生情况.结果:观察组患者在T3时点的MAP和HR明显高于对照组(P<0.05).观察组患者术后6 h、12 h、24 h VAS评分明显低于对照组(P<0.05).观察组患者在恢复室中的二氧化碳分压(PaCO₂)、碱剩余(BE)均高于对照组,动脉血氧分压(PaO₂)明显低于对照组(P<0.05).2组患者术后不良反应发生率比较差异无统计学意义(P>0.05).结论:布托啡诺联合氟比洛芬酯在腹腔镜结肠癌根治术后镇痛优势明显,能有效减轻疼痛,稳定平均动脉压和心率,减少不良反应的发生率,促进术后恢复,但对患者的血气状态存在一定不利影响,临床应用时需关注呼吸功能监测.
Objective To observe the clinical efficacy of butorphanol combined with flurbiprofen axetil for postoperative analgesia after laparoscopic radical resection of colon cancer.Methods A total of 68 patients undergoing laparoscopic radical resection of colon cancer admitted from February 2023 to February 2025 were prospectively enrolled and randomly divided into the control group and the observation group using the random number table method,with 34 cases in each group.The control group received flurbiprofen axetil for postopera-tive analgesia,while the observation group was given butorphanol combined with flurbiprofen axetil.Mean arte-rial pressure(MAP)and heart rate(HR)were compared at immediately after operation(T1),30 min after operation(T2),1 h after operation(T3),2 h after operation(T4),3 h after operation(T5),and 4 h after operation(T6).Visual Analogue Scale(VAS)pain scores at 6 h,12 h,24 h,and 48 h after operation,blood gas indicators at 30 min after admission to the recovery room,and postoperative adverse reactions were also compared between the two groups.Results MAP and HR in the observation group were significantly higher than those in the control group at T3(P<0.05).VAS scores at 6 h,12 h,and 24 h after operation in the obser-vation group were significantly lower than those in the control group(P<0.05).Partial pressure of carbon dioxide(PaCO₂)and base excess(BE)in the observation group were higher than those in the control group,while partial pressure of arterial oxygen(PaO₂)was significantly lower(P<0.05).There was no significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05).Conclu-sion Butorphanol combined with flurbiprofen axetil shows obvious advantages in postoperative analgesia after laparoscopic radical resection of colon cancer.It can effectively relieve pain,stabilize MAP and HR,reduce the incidence of adverse reactions,and promote postoperative recovery.However,it has certain adverse effects on the blood gas status of patients.Therefore,monitoring of respiratory function should be emphasized in clinical application.
聂舜钰;谭周鹏;李尧;吴霜婷
洛阳市中心医院麻醉科(河南 洛阳 471000)洛阳市中心医院麻醉科(河南 洛阳 471000)洛阳市中心医院胃肠外科二病区(河南 洛阳 471000)洛阳市中心医院麻醉科(河南 洛阳 471000)
结肠癌腹腔镜根治术布托啡诺氟比洛芬酯
Colon cancerLaparoscopyRadical resectionButorphanolFlurbiprofen axetil
《中国肛肠病杂志》 2026 (4)
46-49,4
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