茶碱的药理学机制与临床应用研究进展OA
Research Progress on the Pharmacological Mechanism and Clinical Application of Theophylline
茶碱作为一种经典药物,在临床治疗中具有较长的应用历史,目前主要适用于支气管哮喘及慢性阻塞性肺病的治疗.近年来,茶碱的作用机制逐渐被报道,包括抑制磷酸二酯酶,拮抗腺苷受体,上调白细胞介素-10的分泌,下调白细胞介素-8的分泌,影响细胞存活、转录,激活组蛋白脱乙酰酶和增强蛋白磷酸酶2A活性等.此外,茶碱还在神经系统、泌尿系统、心血管系统以及抗肿瘤等方面都具有潜在的治疗价值.文章系统总结了茶碱的作用机制与药理学应用,以期为该药物的深入开发与临床利用提供理论依据.
Theophylline,a well-established therapeutic agent,has a long history of clinical application and is primarily used for the treatment of bronchial asthma and chronic obstructive pulmonary disease(COPD).In recent years,the potential mechanisms of action have been increasingly reported,including phosphodiesterase(PDE)inhibition,adenosine receptor antagonism,up-regulation of Interleukin-10(IL-10)secretion,down-regulation of Interleukin-8(IL-8)secretion,and enhancement of cellular processes such as surviva and,transcription,as well as histone deacetylase activation,and enhancement of protein phosphatase 2A activity.Moreover theophylline has potential therapeutic value in the nervous system,urinary system,cardiovascular system,and anti-tumor.Therefore,this paper systematically reviews the mechanisms of action and pharmacological applications of theophylline,aiming to provide a theoretical basis for the in-depth development and clinical utilization.
李亚男;余莉惠;罗会清;赵世宽;杨瑞娟
云南农业大学食品科学技术学院,云南 昆明 650201云南农业大学食品科学技术学院,云南 昆明 650201云南农业大学食品科学技术学院,云南 昆明 650201云南农业大学食品科学技术学院,云南 昆明 650201云南农业大学食品科学技术学院,云南 昆明 650201
医药卫生
茶碱作用机制药代动力学药理学应用
TheophyllineMechanism of actionPharmacokineticsPharmacological applications
《中国茶叶加工》 2026 (1)
41-46,6
云南省国际科技特派员项目(202403AK140038)
评论