SAR1B在囊泡运输与相关疾病中作用的研究进展OA

The canonical role of secretion-associated Ras-related GTPase 1B(SAR1B)involves the critical regulation of coat protein complex II vesicle formation and budding,as well as the modulation of protein and lipid trans-port.Recent studies have demonstrated that SAR1B also functions as a leucine sensor,modulating the mammalian target of rapamycin complex 1 signaling pathway through leucine-dependent interaction with GTPase-activating protein activity to-ward Rags 2 complex,thereby affecting protein synthesis.In pathological contexts,mutations in SAR1B cause an autoso-mal recessive disorder known as chylomicron retention disease,characterized by fat malabsorption and associated clinical manifestations.Additionally,SAR1B has been implicated in the progression of hepatic and pulmonary tumors and in sus-taining cancer cell survival.This review summarizes the mechanism by which SAR1B promotes vesicle formation and bud-ding,and its multifaceted roles in diverse pathophysiological processes.