Characteristics of humoral and T-cell immune responses in people living with HIV after breakthrough SARS-CoV-2 Omicron variant infection during December 2022 to January 2023OA
Characteristics of humoral and T-cell immune responses in people living with HIV after breakthrough SARS-CoV-2 Omicron variant infection during December 2022 to January 2023
Hai-Bo Ding;Jia-Qi Chen;Jin-Li Song;Hua-Lu Cui;Hai-Long Li;Wen-Qing Geng;Tao Dong;Xiao-Xu Han;Hong Shang;Hong Sun;Yong-Hui Feng;Qing-Hai Hu;Qi Wang;Nan Li;Qing-Qing Ma;Wen Tian;Yan-Chun Peng
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaChinese Academy of Medical Sciences Oxford Institute,Old Road Campus,Oxford OX3 7BN,UK||MRC Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital,Headington Oxford OX3 9DS,UKState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,China||Chinese Academy of Medical Sciences Oxford Institute,Old Road Campus,Oxford OX3 7BN,UKState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases,NHC Key Laboratory of AIDS Prevention and Treatment,National Clinical Research Center for Laboratory Medicine,The First Hospital of China Medical University,China Medical University,Shenyang 110001,China||Key Laboratory of AIDS Immunology,Chinese Academy of Medical Sciences,Shenyang 110001,China||Key Laboratory of AIDS Immunology of Liaoning Province,Shenyang 110001,ChinaChinese Academy of Medical Sciences Oxford Institute,Old Road Campus,Oxford OX3 7BN,UK||MRC Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital,Headington Oxford OX3 9DS,UK
Human immunodeficiency virus(HIV)Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)OmicronAntibody levelsT-cell responseImmune response
Human immunodeficiency virus(HIV)Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)OmicronAntibody levelsT-cell responseImmune response
《中国病毒学》 2026 (1)
84-96,13
This work was supported by the National Key Research and Devel-opment Program of China(2022YFC2304600)the Key Special Project of National Key R&D Program for"Prevention and Control of Major Natural Disasters and Public Safety"(2023YFC3041500)the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS 2018-I2M-2-002)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2023-PT320-01)the China Scholarship Council.We thank all study participants,and their families.We also thank all this follow-up study team.
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