不同术式治疗宫颈高级别鳞状上皮内病变的HPV清除效果比较OA

Objective To compare the human papillomavirus(HPV)clearance effects of cold knife conization(CKC)and total laparoscopic hysterectomy(TLH)in patients with high-grade squamous intraepithelial lesions(HSIL).Methods A total of 200 patients with HSIL who were admitted to Xinxiang Central Hospital between December 2019 and December 2023 were selected as the study subjects.According to the treatment method,they were divided into a CKC group and a TLH group,with 100 patients in each group.The postoperative HPV clearance rate,surgical indicators(operation time,intraoperative blood loss,and length of hospital stay),postoperative follow-up findings(positive surgical margins and residual lesions),and incidence of complications were recorded and analyzed in the two groups.Results There was no statistically significant difference in the HPV clearance rate between the CKC group and the TLH group(P＞0.05).Compared with the TLH group,the CKC group had a shorter operation time and less intraoperative blood loss,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in length of hospital stay between the two groups(P＞0.05).There were no statistically significant differences between the two groups in postoperative positive surgical margins or residual lesions(P＞0.05).There was also no statistically significant difference in the incidence of complications between the two groups(P＞0.05).Conclusion There was no statistically significant difference in the 12-month postoperative HPV clearance rate between CKC and TLH.CKC has advantages in terms of operation time and intraoperative blood loss.There were no statistically significant differences between the two groups in postoperative positive surgical margins,residual lesions,or incidence of complications.In clinical practice,the surgical procedure should be selected individually according to the patient's age,extent of the lesion,follow-up compliance,and coexistence of gynecological diseases.