二氯乙酸盐在炎症性疾病中抗炎作用的研究进展OA

Dichloroacetate(DCA)is a pan-inhibitor of pyruvate dehydrogenase kinase(PDK).PDK inhibits the pyru-vate dehydrogenase complex(PDC),thereby promoting a shift in cellular metabolism from oxidative phosphorylation towards aero-bic glycolysis(the Warburg effect).By inhibiting PDK,DCA activates PDC,reverses aerobic glycolysis,enhances mitochondrial oxidative phosphorylation,and reduces lactate production.In recent years,with the in-depth study of the glycolytic pathway in tumors and inflammatory diseases,an increasing number of studies have revealed the potential clinical value of DCA in inflamma-tory diseases.This article reviews the research progress regarding the anti-inflammatory activity and mechanisms of DCA in various inflammatory diseases,aiming to provide references for both basic research and clinical applications of DCA in these conditions,as well as to offer new perspectives for the treatment of inflammatory diseases.