异丙托溴铵对慢阻肺患者血清免疫相关指标及气道重塑的影响OA
Effects of Ipratropium Bromide on Serum Immune Related Indexes and Airway Remodeling in Patients with Chronic Obstructive Pulmonary Disease
目的 探讨异丙托溴铵治疗慢阻肺患者的效果及对患者血清免疫相关指标及气道重塑的影响.方法 按照随机数字表法将湖口县人民医院呼吸内科 2020 年 11 月-2024 年 10 月收治的 100 例慢阻肺患者分为对照组 50 例和研究组 50 例.对照组患者应用布地奈德治疗,研究组患者以雾化吸入异丙托溴铵治疗.比较两组治疗效率、血清免疫相关指标[血清免疫球蛋白A(IgA)、血清免疫球蛋白G(IgG)、血清免疫球蛋白M(IgM)]、气道重塑情况[基质金属蛋白酶抑制因子 1(TIMP1)、碱性成纤维细胞生长因子(b-FGF)、基质金属蛋白酶 9(MMP-9)、神经生长因子(NGF)]以及肺功能指标[用力肺活量(FVC)、第 1s用力呼气容积(FEV1)、呼气峰值流速(PEF)、FEV1/FVC].结果 总有效率方面,研究组高于对照组(P＜0.05).与对照组治疗后的血清免疫相关指标、气道重塑情况及肺功能指标相比,研究组IgG、IgM、IgA水平更高,TIMP1、b-FGF、MMP-9、NGF水平更低,且FEV1、FVC、FEV1/FVC、PEF更高(P＜0.05).结论 慢阻肺治疗中,异丙托溴铵雾化应用的临床疗效良好,能提高患者免疫功能和肺功能,有利于患者气道重塑,适宜推广及应用.
Objective To investigate the effects of ipratropium bromide in treating patients with chronic obstructive pulmonary disease and its effect on serum immune-related indicators and airway remodeling.Methods A total of 100 patients with chronic obstructive pulmonary disease,admitted to the Department of Respiratory Medicine at Hukou County People's Hospital from November 2020 to October 2024,were enrolled and randomly assigned via a random number table method into a control group(n=50)and a study group(n=50).The control group received treatment with budesonide,whereas the study group was administered ipratropium bromide via aerosol inhalation.The treatment efficiency,serum immune-related indexes[serum immunoglobulin A(IgA),serum immunoglobulin G(IgG),serum immunoglobulin M(IgM)],airway remodeling[tissue Inhibitor of Metalloproteinase 1(TIMP1),basic fibroblast growth factor(b-FGF),matrix metalloproteinase 9(MMP-9),nerve growth factor(NGF)],pulmonary function[forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),peak expiratory flow(PEF),FEV1/FVC]were compared between the two groups.Results In terms of total response rate,the study group demonstrated a significantly higher rate than the control group(P＜0.05).Compared with the control group in terms of serum immune-related indicators,airway remodeling status,and pulmonary function parameters after treatment,the study group exhibited significantly higher levels of IgG,IgM,and IgA,significantly lower levels of TIMP1,b-FGF,MMP-9,and NGF,as well as markedly elevated values of FEV1,FVC,FEV1/FVC,and PEF when compared with the control group(P＜0.05).Conclusion In the treatment of chronic obstructive pulmonary disease,the administration of ipratropium bromide via aerosol inhalation achieved satisfactory clinical outcomes,significantly enhancing patients'immune and pulmonary functions and contributing to favorable airway remodeling,thereby representing a therapeutic approach that is well-suited for broader clinical implementation.
王骏莉
湖口县人民医院呼吸内科,江西 湖口 332500
医药卫生
异丙托溴铵慢阻肺血清免疫相关指标气道重塑
Ipratropium bromideChronic obstructive pulmonary diseaseSerum immune-related indexesAirway remodeling
《医学信息》 2026 (8)
139-143,5
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