基于数据挖掘分析中药复方保肝护肝的用药规律OA

Objective To explore the medication rules of traditional Chinese medicine compounds for hepatoprotection,and to provide a scientific basis for the development of hepatoprotective products.Methods The literature was retrieved from databases including China National Knowledge Infrastructure(CNKI),WANFANG DATA,VIP,SinoMed,and others until July 25,2024.The keywords such as"liver injury""alcoholic liver"and"hepatoprotection"were searched,relevant literatures were collected,traditional Chinese medicine compounds were screened,and an effective database was established.The frequency and dose distribution of Chinese herbs were statistically analyzed.The core drugs in the compound were identified by high-frequency Chinese medicine factor analysis,cluster analysis and related rule analysis,to study the medication rules of Chinese medicine compound for hepatoprotection.Results A total of 143 prescriptions were collected,involving 239 Chinese herbs with a total frequency of 1399 times,of which 39 herbs were used more than 10 times,and the most frequently used was Poria,with a utilization rate of 46.15%.The overall dosage of Poria,Radix Puerariae,virgate wormwood herb and Fructus Crataegi were relatively high,while that of Radix et Rhizoma Glycyrrhizae was relatively low.Chinese herbs such as Poria,Radix et Rhizoma Glycyrrhizae and Radix Puerariae were often used in combination with each other in the treatment prescription,they were the core of the traditional Chinese medicine compound for hepatoprotection.Conclusion Data mining reveals the pattern of drug use and dosage of traditional Chinese medicine compound with Poria,Radix et Rhizoma Glycyrrhizae,Radix Puerariae and Semen Hoveniae as the core compatibility,and provides theoretical support and scientific basis for the development of traditional Chinese medicine compound for hepatoprotection.