益肾健骨合剂结合针刀治疗骨质疏松慢性腰背痛OA
Yishen Jiangu Mixture Combined with Needle Knife Therapy for the Treatment of Chronic Back Pain Caused by Osteoporosis
目的:评价益肾健骨合剂结合针刀治疗脾肾阳虚型原发性骨质疏松慢性腰背痛的临床效果.方法:选取150例患者,根据随机数字法平均分为3组.对照组:碳酸钙咀嚼片+阿法 D3口服6个月;观察组 A:在对照组疗法的基础上,联合益肾健骨合剂口服6个月;观察组B:观察组 A疗法的基础上,联合小针刀治疗,1周1次,3次为1个疗程,最多治疗2个疗程.观察统计治疗1个月、3个月、6个月后 VAS(视觉模拟疼痛评分)、ODI(Oswestry功能障碍指数)、PINP(Ⅰ型原胶原 N-端前肽)、CTX(Ⅰ型胶原C端肽)、PGE2(前列腺素E2)、中医证候评分及血常规、肝肾功能的变化,并记录患者出现的不良药物反应.结果:治疗前3组患者VAS评分、ODI评分、PINP、CTX、PGE2、中医证候评分比较,差异均无统计学意义(P>0.05);治疗1个月、3个月、6个月后,3组患者 VAS评分、ODI评分、PINP、CTX、PGE2、中医证候评分均逐步降低,3组差异有统计学意义(P<0.05),观察组B的评分情况明显优于观察组 A 和对照组.3组患者血常规、肝肾功能及不良反应,差异无统计学意义(P>0.05).结论:益肾健骨合剂结合小针刀可通过调节骨代谢、降低骨转换率、抑制骨丢失、减少炎性致痛因子,有效缓解脾肾阳虚型骨质疏松慢性腰背痛,改善腰部活动功能,综合疗效满意,安全性高.
Objective:To evaluate the clinical efficacy of Yishen Jiangu Mixture combined with needle knife therapy in the treatment of chronic low back pain caused by primary osteoporosis of spleen-kidney Yang deficiency type.Methods:150 patients were selected and divided into 3 groups using random number method.Control group:treated with calcium carbonate chewable tablets and alpha D3 for 6 months;Observation group A:On the basis of the control group,com-bined with or Yishen Jiangu Mixture,persisted in treatment for 6 months;Observation group B:On the basis of obser-vation group A combined with small needle knife treatment once a week,three times for one course of treatment,up to two courses of treatment.Observe and statistically analyze the changes in VAS(Visual Analogue Scale),ODI(Oswe-stry Disability Index),PINP(N-terminal propeptide of type I precollagen),CTX(carboxy-terminal telopeptide of type I collagen),PGE2(Prostaglandin E2),TCM(traditional Chinese medicine)syndrome score,blood routine,liver and kid-ney function at 1、3 and 6 months after treatment,and record any adverse drug reactions that occur in patients.Results:There were not significant differences in VAS score、ODI score、PINP、CTX、PGE2 and TCM syndrome score before treatment(P<0.05).The VAS score、ODI score、PINP、CTX、PGE2 and TCM syndrome score of among the 3 grups were gradually decreasing after treatment of 1 month、3 months and 6 months,while there were significant differences between them(P<0.05),and Observation group B was better than Observation group A and Control group.There were no significant differences in blood routine,liver and kidney function,and adverse reactions among the 3 groups(P>0.05).Conclusion:The combination of Yishen Jiangu Mixture and small needle knife can effectively alleviate chronic low back pain and improve lumbar mobility in patients with primary osteoporosis of spleen-kidney Yang deficiency type,by regulating bone metabolism,reducing bone turnover rate,inhibiting bone loss,and reducing inflammatory pain factors.The comprehensive efficacy is satisfactory and the safety is high.
张魁贤;王智杭;陈海东;余程威;吴惠明
浙江中医药大学附属温州市中医院,浙江 温州 325000浙江中医药大学附属温州市中医院,浙江 温州 325000浙江中医药大学附属温州市中医院,浙江 温州 325000浙江中医药大学附属温州市中医院,浙江 温州 325000浙江中医药大学附属温州市中医院,浙江 温州 325000
医药卫生
针刀益肾健骨合剂脾肾阳虚骨质疏松腰背痛
needle knifeYishen Jiangu Mixturespleen-kidney yang deficiencyosteoporosislow back pain
《亚太传统医药》 2026 (5)
83-87,5
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