基于"虚气留滞"理论探讨冠心病合并抑郁状态的药食同源治疗策略OA

In Chinese medicine theory,coronary heart disease(CHD)complicated with depressive state falls into the categories of"chest bi-impediment/cardiac pain"and"depressive disorder."It is believed that the core pathogenesis is"qi deficiency leading to pathogenic accumulation."That is,spleen qi deficiency is the initiating pathogenesis,while stagnation of qi,phlegm,and blood stasis constitutes the direct pathogenesis.These two aspects are mutually causative,leading to the coexistence of heart vessel obstruction and malnourishment of heart spirit,manifesting as an intertwined state of bi-impediment disorder and depressive disorder.Based on Academician WANG Yongyan's theory of"qi deficiency leading to pathogenic accumulation",our research group proposes a therapeutic approach of"supplementing deficiency and resolving accumulation,and simultaneously regulating bi-impediment disorder and depressive disorder."This principle advocates strengthening the spleen and supplementing qi to treat the root,and circulating qi,transforming phlegm,and circulating blood to address the manifestations.The modified Yangxin Tongluo Paste is used to achieve a comprehensive treatment that takes into account both the heart and spleen,regulates both qi and blood,and simultaneously addresses bi-impediment disorder and depressive disorder.