玉竹"益胃阴,润肺燥"功效的现代药理机制与临床应用研究进展OA

Yuzhu(Polygonati Odorati Rhizoma)is a traditional Chinese medicinal and food-medicine homologous herb,among which"Xiang Yuzhu"(produced in Hunan Province)is considered the most authentic variety,possessing the clinical efficacy of"nourishing stomach yin and moistening lung dryness."This paper systematically reviews the historical evolution of the theory of"lung-stomach simultaneous treatment"with Yuzhu(Polygonati Odorati Rhizoma)and summarizes its modern biological mechanisms.This theory originated from the meridian affinity described in the Shen Nong Ben Cao Jing(Shen Nong's Classic of the Materia Medica),gradually clarified the zang-fu organ localization from the Wei-Jin to Tang-Song dynasties,formed the"lung-stomach simultaneous treatment"theory during the Jin-Yuan period,and was finally established through the application of classic formulas in the Ming-Qing dynasties.The effects of Yuzhu(Polygonati Odorati Rhizoma)in"nourishing stomach yin"is primarily achieved by protecting the gastric mucosa,promoting its repair,regulating glucose metabolism,and improving gastrointestinal motility,and is applied in conditions such as chronic atrophic gastritis and diabetes characterized by stomach yin deficiency.Its ability of"moistening lung dryness"relies on anti-inflammatory,immunomodulatory,and anti-pulmonary fibrosis pathways,and it is commonly used in chronic obstructive pulmonary disease,pulmonary fibrosis,lung cancer,and other conditions marked by lung yin deficiency with dryness-heat pattern.The material basis of Yuzhu(Polygonati Odorati Rhizoma)is centered on polysaccharides and steroidal saponins,exhibiting a dual regulatory pattern on the digestive and respiratory systems via"multiple components-multiple targets-multiple pathways".However,current research is mostly limited to phenotypic validation using single organs and crude extracts.Challenges remain in revealing the synergistic mechanism of the"lung-gut axis",clarifying target-binding evidence of core components,and establishing a comprehensive quality evaluation system linked to traditional efficacy.