钙化性主动脉瓣疾病的分子致病机制及其药物治疗研究进展OA

Calcific aortic valve disease(CAVD)has become one of the most common heart valve diseases worldwide,with a significantly increased incidence among the elderly.The pathological features of this disease include progressive fibrosis and calcium salt deposition in the aortic valve leaflets,leading to valve thickening,hardening,and eventually aortic stenosis,which seriously affects cardiac function and increases the risk of cardiovascular events.In recent years,with the rapid develop-ment of molecular biology,imaging,and other fields,significant progress has been made in the study of its pathogenesis,re-vealing that this disease is not a simple degenerative lesion but an active,complex,and controllable pathological process invol-ving multiple molecular and cellular pathways.This review aims to systematically summarize the research progress in the epi-demiology,pathogenesis,and treatment strategies of calcific aortic valve disease,focusing on the roles of key factors such as inflammatory response and lipid metabolism abnormalities in the disease's occurrence and development,and to look forward to the limitations of current research and future directions,with the aim of providing a theoretical basis for early diagnosis,precise intervention,and new drug development.