低强度脉冲超声参数对骨小梁和成骨细胞力学分布影响的模拟研究OA

Objective To study the effect of low-intensity pulsed ultrasound(LIPUS)parameters interaction on the stress distribution of trabecular bone and osteoblasts with the finite element method,so as to provide insights for the prevention and treatment of osteoporosis.Methods A three-dimensional finite element model of cancellous bone including trabecular bone,bone marrow fluid and osteoblasts(including nucleus)was constructed with COMSOL Multiphysics 6.1 software.A simulation study was carried out for the operating condition involving no ultrasound and those formed by pairing different LIPUS parameters(sound intensity I of 10,20,30,40 and 50 mW/cm² and duty cycles(DC)of 10%,20%,25%,33%and 50%),in order to analyze the stress distribution in trabecular bone and osteoblasts(including nucleus)under each condition.Results The LIPUS significantly affected the von Mises stress distribution in trabecular bone and osteoblasts(including nucleus),with von Mises stress at the cell nucleus being significantly higher than in other regions of the cell.The von Mises stress in trabecular bone was positively correlated with both sound intensity I and DC;the von Mises stress in osteoblasts(including nucleus)was positively correlated with sound intensity I,and the average von Mises stress was the highest when DC was 33%.Conclusion Under the influence of LIPUS,the mechanical distribution patterns of trabecular bone and osteob-lasts(including nucleus)exhibit significant parameter-dependent characteristics;and ultrasound parameters can be preci-sely adjusted as needed to prevent and treat osteoporosis.[Chinese Medical Equipment Journal,2026,47(2):44-50]