神经内镜下经鼻蝶切除术与显微镜下经鼻蝶切除术治疗鞍区肿瘤的效果对比OA

Objective To compare and analyze the clinical efficacy of neuroendoscopic transsphenoidal resection and microscopic transsphenoidal resection in the treatment of sellar region tumors.Methods A total of 77 patients with sellar region tumors admitted to our hospital from January 2021 to September 2024 were selected and divided into the neuroendoscopic group(n=40,treated with neuroendoscopic transsphenoidal resection)and microscopic group(n=37,treated with microscopic transsphenoidal resection)according to different surgical procedures.The total tumor resection rate,perioperative indicators,visual function[visual field index(VFI),pattern standard deviation(PSD)],hormone[growth hormone(GH),adrenocorticotropic hormone(ACTH),prolactin(PRL)]levels and complication rate were compared between the two groups.Results The total tumor resection rate in the neuroendoscopic group was 92.50%(37/40),significantly higher than 75.68%(28/37)in the microscopic group(P<0.05).The length of hospital stay was significantly shorter and intraoperative blood loss was significantly less in the neuroendoscopic group than those in the microscopic group(P<0.05).At 1 month postoperatively,the neuroendoscopic group showed significantly higher VFI and lower PSD than the microscopic group(P<0.05).At 7 days postoperatively,the serum levels of GH,ACTH,and PRL in the neuroendoscopic group were significantly lower than those in the microscopic group(P<0.05).The total complication rate in the neuroendoscopic group was 2.50%(1/40),significantly lower than 21.62%(8/37)in the microscopic group(P<0.05).Conclusions Compared with microscopic transsphenoidal resection,neuroendoscopic transsphenoidal resection applied in the treatment of sellar region tumors can significantly improve the total tumor resection rate,reduce intraoperative blood loss,promote the recovery of visual function,lower the risk of abnormal hormone secretion and complications,and accelerate the rehabilitation process of patients.