基于数据挖掘分析中医药治疗帕金森病的方证及用药规律OA

Objective:To explore the prescription-syndrome type and medication rules of traditional Chinese medicine(TCM)in treating Parkinson's disease(PD)by conducting a multi-dimensional data mining analysis of relevant medical case literature.Methods:Literature published from the inception of databases including CNKI,VIP,Wanfang,and CBM until February 15,2025,was retrieved.A PD medication database was established via Excel.High-frequency Chinese herbs(frequency≥10)were analyzed via Lantern 5.0 and Rstudio software for latent structure modeling,comprehensive clustering,and association rule mining.Results:A total of 239 prescriptions involving 187 Chinese herbs with a total frequency of 2 802 occurrences were included.The top 5 high-frequency herbs were Paeoniae Radix Alba,Gastrodiae Rhizoma,Rehmanniae Radix Praeparata,Angelicae Sinensis Radix,and Glycyrrhizae Radix et Rhizoma.Herbal natures were primarily warm,cold,and neutral;flavors were mainly sweet,bitter,and acrid;channel entries were predominantly the liver,kidney,and spleen channels.The primary effect category was deficiency-supplementing herbs,followed by liver-calming and wind-suppressing herbs.The latent structure model identified 19 latent variables,38 latent classes,and 5 comprehensive clustering models,leading to the summarization of 14 core prescriptions.The main TCM syndrome types of PD were inferred as wind stirring due to phlegm-heat,qi and blood deficiency,insufficiency of the marrow sea,yin deficiency of the liver and kidney,and wind stirring due to blood stasis.Association rule analysis yielded 18 strong rules.The rule"Angelicae Sinensis Radix+Rehmanniae Radix Praeparata → Paeoniae Radix Alba"had the highest support,while the rules"Testudinis Carapax et Plastrum+Ostreae Concha → Paeoniae Radix Alba"and"Angelicae Sinensis Radix+Puerariae Lobatae Radix→Paeoniae Radix Alba"had the highest confidence.Conclusion:The pathogenesis of PD is characterized by a root deficiency(yin deficiency of the liver and kidney,qi and blood deficiency)and branch excess(wind,fire,phlegm,stasis).The treatment should focus on clearing heat,resolving phlegm,boosting qi,and nourishing blood,assisted by suppressing wind and unblocking collaterals.