中药多靶点缓解炎性疼痛的作用机制研究进展OA
Research Progress on the Mechanisms of Multi-Target Traditional Chinese Medicine in Alleviating Inflammatory Pain
炎性疼痛作为一种临床常见症状,给患者造成生理与心理双重影响,且发病机制复杂.临床上常使用非甾体抗炎药及阿片类镇痛药等类型的药物来治疗炎性痛,但长期使用可导致患者出现胃肠道出血及成瘾性等不良反应.本文系统梳理了中药从调控炎症通路、干预痛觉敏化、调控免疫细胞及抗氧化等多角度缓解炎性疼痛的最新进展,为以后开发镇痛药物提供一些参考.
Inflammatory pain,a common clinical symptom,exerts dual physical and psychological impacts on patients,and its patho-genesis is complex.In clinical practice,non-steroidal anti-inflammatory drugs,opioid analgesics,and other types of drugs are often used to treat inflammatory pain.However,prolonged use may result in adverse effects,including gastrointestinal bleeding and dependency.This arti-cle systematically reviews the latest progress of traditional Chinese medicine in relieving inflammatory pain from multiple perspectives,such as regulating inflammatory pathways,interfering with hyperalgesia,regulating immune cells and anti-oxidation,so as to provide some refer-ences for the development of analgesic drugs in the future.
韩雪;闵清
湖北科技学院医学部药学院,湖北咸宁 437100||鄂南特色中药湖北省工程研究中心湖北科技学院医学部药学院,湖北咸宁 437100||鄂南特色中药湖北省工程研究中心
医药卫生
中药炎性疼痛炎症通路痛觉敏化
Traditional Chinese medicineInflammatory painInflammatory pathwaysHyperalgesia
《湖北科技学院学报(医学版)》 2026 (2)
174-178,5
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