多形性腺瘤样基因1在畜禽生长发育中的研究进展OA

The advancement of animal genomics has progressively established the zinc-finger transcription factor PLAG1(pleomorphic ade-noma gene 1)as a central regulator in early growth and body size determination in animals.This review systematically elucidates the biologi-cal significance of this gene from three key dimensions.Firstly,it focuses on clarifying the molecular basis by which PLAG1,as a nuclear transcription factor,regulates cell proliferation,differentiation,and apoptosis through promoter-specific binding.Subsequently,it evaluates the association strength between its genetic variants—including single nucleotide polymorphism(SNP),insertions/deletion(InDel),and copy number variation(CNV)—and growth traits in livestock and poultry,along with delineating the practical boundaries for their applica-tion in breeding programs.Finally,it constructs a transcriptional regulatory network orchestrated by PLAG1,revealing its dynamic mechanism in coordinating skeletal muscle development through multi-level cascade pathways.These findings not only deepen our under-standing of the principles governing muscle development in domestic animals but,more importantly,provide actionable molecular targets for precision breeding.