常山铁苋菜青蒿菊粉复方对鸡球虫病的防治效果研究OA

In order to evaluate the anticoccidial effect,growth performance and intestinal flora of Chinese herbal compound composed of Changshan,Acalypha australis,Artemisia annua and inulin on coccidiosis-infected chickens,150 healthy chickens were obtained and ran-domly divided into 6 groups(the blank control group,the diclazuril group,the low/medium/high dose Chinese herbal compound groups and the infection control group).A coccidiosis infection model was established by artificial challenge with Eimeria tenella.Then,the weight gain,feed conversion rate,anticoccidial index(ACI)and cecal histopathological changes of each group were evaluated,and the diversity of intes-tinal flora was analyzed by 16S rDNA sequencing.The results showed that the growth performance of the chickens infected with Eimeria tenel-la was significantly improved by middle and high doses of Chinese herbal compound.However,there was no significant difference in the aver-age weight gain between the middle and high dose groups and the diclazuril group(P＞0.05),but the feed conversion rate(1.95%-2.03%)was close to the blank control group(2.16%).The anticoccidial index(ACI)was157,which was significantly better than that of the infected control group.The analysis of intestinal flora showed that the Chinese herbal compound up-regulated the relative abundance of Firmicutes and Rothia,and down-regulated the abnormal proliferation of Bacteroidetes,Proteobacteria and Prevotella.The traditional Chinese medicine compound composed of Dichroa febrifuga,Acalypha australis,Artemisia annua and inulin produced a good anticoccidial effect.Compared with the infection control group,it can improve the diversity of intestinal flora in the treated chicks and improved the struc-ture of their intestinal flora,which had a beneficial effect on the body.