强化饮食营养联合运动干预对黑色素瘤伴肌肉减少症患者营养状态和健康状况的影响OA

Objective To investigate the effects of enhanced dietary nutrition combined with exercise intervention on the nutritional status and health of patients with melanoma and sarcopenia.Methods Ninety eight melanoma patients with sarcopenia admitted to the melanoma oncology department of our hospital from June 2023 to October 2024 were randomly divided into a control group and an study group,with 49 patients in each group.The control group received routine nutritional and exercise interventions,while the study group received intensified dietary nutrition and exercise based on the control group's regimen.Both groups were in-tervened for 12 weeks.the nutritional status[serum hemoglobin,prealbumin,albumin],muscle function[u-sing skeletal muscle index skeletal muscle index(SMI),grip strength,and daily walking speed],quality of life using Karnofsky Performance Status(KPS)score,and incidence of adverse reactions to anti-tumor treatment between two groups of patients were compared.Results Before the intervention,there were no statistically significant differences in nutritional status between the two groups(P>0.05).After the intervention,the lev-els of serum hemoglobin,prealbumin,and albumin in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).Before the intervention,there were no statisti-cally significant differences in muscle function between the two groups(P>0.05).After the intervention,the study group's SMI,grip strength,and usual gait speed were all greater than those of the control group,the differences were statistically significant(P<0.05).Before the intervention,there were no statistically signifi-cant differences in KPS scores for quality of life between the two groups(P>0.05).After the intervention,the KPS scores for quality of life in the study group were all higher than those in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions to antitumor therapy in the study group was lower than in the control group,the difference was statistically significant(P<0.05).Conclusion Compared with regular nutrition combined exercise intervention,enhanced dietary nutrition combined with ex-ercise intervention can more effectively improve the nutritional status of patients with melanoma and sarcope-nia,enhance muscle function,improve quality of life,and reduce the incidence of adverse reactions to antitumor therapy.